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Tramadol is an effective pain
reliever. Its mode of action resembles that of
narcotics, but it has significantly less potential for
abuse and addiction than the narcotics. Tramadol is as
effective as narcotics in relieving pain but does not
depress respiration, a side effect of most narcotics.
Tramadol is not a nonsteroidal antiinflammatory drug (NSAID),
and does not have the increased risk of stomach
ulceration and internal bleeding that can occur with the
use of NSAIDs
Ultracet is a combination of two drugs, tramadol
(Ultram) and acetaminophen (Tylenol), that is used to
relieve moderate, acute pain such as pain following
dental or surgical procedures. Tramadol and
acetaminophen each relieve pain, but they do so by
different mechanisms. Tramadol achieves pain relief in
two ways. It binds to the µ-opioid receptor on nerves
(the same mechanism that is responsible for the
effectives of narcotics, such as morphine), and it also
inhibits the reuptake of serotonin and norepinephrine by
nerves. This inhibition may lead to reduced transmission
of pain signals through the spinal cord to the brain.
Acetaminophen achieves pain relief in the spinal cord
and brain by increasing the threshold to pain, that is,
by increasing the strength of the painful stimulus that
is necessary in order to give rise to the sensation of
pain. It does this by inhibiting an enzyme that makes
prostaglandins. Ultracet was approved by the FDA in
2001.
Acute pain results from disease, inflammation, or injury
to tissues. This type of pain generally comes on
suddenly, for example, after trauma or surgery, and may
be accompanied by anxiety or emotional distress. The
cause of acute pain can usually be diagnosed and
treated, and the pain is confined to a given period of
time and severity. In some instances, it can become
chronic.
Chronic pain is widely believed to represent disease
itself. It can be made much worse by environmental and
psychological factors. Chronic pain persists over a
longer period of time than acute pain and is resistant
to most medical treatments. It can-and often does-cause
severe problems for patients.
Pain warns us that something isn't quite right, that we
should take medicine or see a doctor. At its worst,
however, pain robs us of our productivity, our
well-being, and, for many of us suffering from extended
illness, our very lives. Pain is a complex perception
that differs enormously among individuals, even those
who appear to have identical injuries or illnesses.
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